Drug target validation: Hitting the target

نویسندگان

چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Hitting an uncertain target

Experiments in which monkeys have to select or estimate the location of a target are revealing more about the role of the dorsal premotor cortex in decision making.

متن کامل

A Modified Proportional Navigation Guidance for Accurate Target Hitting

When a detector sensitive to the target plume IR seeker is used for tracking airborne targets, the seeker tends to follow the target hot point which is a point farther away from the target exhaust and its fuselage. In order to increase the missile effectiveness, it is necessary to modify the guidance law by adding a lead bias command. The resulting guidance is known as target adaptive guidance ...

متن کامل

Target validation: A door to drug discovery.

From ancient times to today, drug discovery transitioned from serendipity to rationality over its long history. Proper drug target selection and validation are crucial to the discovery of new drugs. This review discusses the definition of drug targets and proposes several characteristics for drug targets. The limitations of the term 'target' itself are summarized. The drug target validation pro...

متن کامل

Hitting the target in IDH2 mutant AML.

A block in myeloid differentiation is a hallmark ofAML.Undifferentiated blast cells with enhanced self-renewal capabilities can accumulate in the bone marrow. When these undifferentiated cells acquire properties that provide a proliferative advantage, AML may arise. It has long been hypothesized that overcoming the differentiation block in AML would be an important component of improved treatme...

متن کامل

Anti-Tau Antibodies: Hitting the Target

Immunotherapies targeting tau in mouse models of human tauopathies could have disease-modifying effects. In this issue of Neuron, Yanamandra et al. (2013) use tau antibodies, which effectively block tau seeding in culture, to attenuate tauopathy and improve cognition in mutant tau mouse models.

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Nature

سال: 2003

ISSN: 0028-0836,1476-4687

DOI: 10.1038/422341a